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Never was "injecting drug use" even with a well-known moment of the townsfolk "arrival" (a fundamental moment in heroin abuse was intravenously), or something even remotely similar; no drug treatment clinics with the inscription "kratomomaniya" no kratom and "on the streets" along with basic drugs and stuff. But also clearly see that the surfactant kratom - really show agonist properties is primarily a mu-opioid receptor, and of the sale and purchase of kratom in "clear" stores - this is the case, as well as the illegality of kratom in Thailand and much more. So, what we are talking? After all, some enteomagaziny, one of which, as an example I cited, for example, provide only Kratom, while all clearly stated that it was "not for human ingestion" and - "for research and collections." And yet, as though it may sound, many people actually acquire the entheogen and do research.

The chemical nature of the "main" Kratom alkaloids - is well known: it is, oddly enough, indole derivatives, very similar in this respect to a number of alkaloid yohimbe, Rauwolfia, and even the "cat's claw" - the famous vines with proven activity against the activation of the immune system. The only thing that really amazes - is the presence of a methoxy group in the known, in terms of chemistry, "psychedelic tryptamine position" like psilocybin and LSD, because we know definitely that it is the presence in this position in the "classic" tryptamine psychedelics and other hydroxyl groups (in general, psilocybin undergoes hydrolysis in the body and as a result, as in the case mitradzhinine ave. kratom basic alkaloids, in the human body such surfactants are metabolized by "separation" methyl (or otherwise) with the remainder of the fragment is a hydroxyl group); If we talk about LSD, it is in general a complex tetracyclic psychedelic surfactant, but there has substitution in this fragment of the indole "foundation"). It should be moved to psilocin this hydroxyl group in the 5th position, and get at least the easiest and positional isomer of psilocin (ie, exactly the same structure, but with a different arrangement of the hydroxyl group) - and there is quite a different plan bufotenin, which, though showing in large doses psychedelic activity are not comparable and the "quality" and the duration of the effects of psilocin, but is quite different, quite dangerous surfactants often present in the skin of some toads in a number of higher and lower plants. It is also clear that mitradzhinin and its analogues in kratom - more "close" to the so-called "Fused indole derivatives - beta-carbolines on the similarity of harmine and its analogues, but these surfactants are more simple, and well known for their toxicity (irreversible MAOIs), although this group of surfactants gave" push "to create highly effective, well-known in psychiatry, antidepressants, MAOIs-A, as a rule, with a challenging and even nootropic activity: pirazidol, inkazan, tetrindol and some others. It should be noted that the structure of the PLC resemble only one "part" of the surfactant molecules like kratom mitradzhinina (indole), and in terms of pharmacological properties, it's totally different matter. On the other hand, if it is considered "indole" mitradzhinina moiety and its derivatives, it can be seen (comparison of conventional crude) was substitution "in the 4-position" (if it was a simple mitradzhinin tryptamine psilocybin on similarity). Simply put, these Kratom alkaloids were supposed to be pronounced SAW psychedelic, but here we have the phenomenon: mitradzhinin and other surfactants kratom - are not MAOIs, but also did not show any significant psychedelic properties, so characteristic of simple tryptamine derivatives like psilocin.

So obviously that kratom surfactants - even though it indole derivatives and substitution are typically simpler to "tryptamine psychedelic" place, they nevertheless remotely and do not exhibit an inherent simply as "tryptamine psychedelic drugs" on the similarity psilocybin and more complex, as an example in the case of harmine derivatives, not to mention the specific properties of the above-mentioned examples, AD-MAOI.

The most correct of kratom in terms of information in Wikipedia and other sources, is this piece describing botany plants:

"Kratom (Mitragyna speciosa) - a large tree native to Southeast Asia, belonging to the family Rubiaceae, first described by the Dutch colonial explorer by the name of Korthals. This species belongs to the botanical term for such plants as Corynanthe, Cinchona and Uncaria and similar to them in the biochemical sense. Kratom is in the same family as the coffee tree and psychoactive plant Psychotria viridis".

It is this description allows you to explore the biochemistry of kratom, comparing the structure of its alkaloids alkaloids with structures "related plants." The most "close" kratom in this regard is Yohimbe tree.

I was originally told that bring the most general information about kratom, it is possible that in the near future will be available with this plant is much more deeply. Why is it all necessary? Yes, if only because if you rely only on the available (open) inquire about this really amazing plants, of course, we can expect not only the appearance of terms like "opioid", but also the kind of "kokainopodobny stimulant." Considerable importance is and what form of kratom and for what purposes are taken by mouth, as in this case, the pharmacological effects may be very different.

I raise the topic of kratom also because it's the entheogen that efficacy and minimal toxicity, comparable to medical cannabis and other drugs such as cannabis, which is becoming more widespread and successful use in developed countries, and in the first place - the treatment of the most sinister disease where malignant oncology - is not "everything", but rather a sort of "tip of the iceberg." The most important, in my view, the side of the matter is that in reality very small percentage of people are using the same cannabis solely as a PLC, and it is clear that in the name of "Medical marijuana" - can only guess at what lies in the fact, it is, as they say, "silk purse" for many, and today it is the recreational use of cannabis - it is a problem, but this topic deserves special scrutiny.

If we talk about the "most powerful" varieties of kratom, or about the powerful "aqueous extracts", "or a" balanced mix "most active surfactants plants (standardized amount of alkaloids), then even though we read that something there" 50 times more potent than morphine, "and so forth. in practice, we have in fact quite different. The level of strictly" opioid "kratom effect, even in the case of extracts, compared with effects typically either codeine or tramadol, or - hydrocodone, etc. and mixed opioid central analgesics, but no one has yet described the effects of kratom as "comparable to the effects of heroin / morphine." Well, apart from that we should not forget about the basic structures of atypical kratom alkaloids exhibiting agonist properties of mu-opioid receptors, in chemical terms the most "close "analogue for these alkaloids among opioid analgesics, to some extent, such as PLC etonitazen and its derivatives, but the comparison is very, very conditional.

In my humble opinion, the comparison of the structure mitradzhinina or 7 Gidroksimitradzhinina (today it is the main candidate for the seat of the main surfactant kratom, before it was considered that mitradzhinin is responsible for the main effects) with the structure of beta-prodina - one of the first fully synthetic opioid analgesics are applied in medical practice - at least incorrect, though quite symbolic: after the total synthesis of morphine, his active research scientists unexpectedly discovered morphine-like properties in petidinovoy acid and its derivatives. Psychopharmacology is well-known so-called "Transcription morphine Schaumann" and the concept of "Morphine Rules".

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